By Gabriella Castoria, Antimo Migliaccio
Breast and prostate cancers are either hormone-dependent, a minimum of in a few phases in their development. Hormonal manipulation represents a major healing strategy. even though so much of breast and prostate cancers before everything reply to hormone remedy, such a lot tumors reinitiate to development. eventually, hormone-resistant and metastatic breast and prostate cancers may perhaps improve. hence, the problem is the dissection of mechanisms in which steroid receptor signaling pathways proceed to persuade telephone progress and invasiveness. Compelling facts shows that steroid hormones elicit non-genomic responses in extra-nuclear compartment of objective cells. during this mobile situation, steroid-coupled receptors quickly recruit signaling effectors or scaffold proteins and turn on a number of pathways resulting in proliferation, survival, migration and invasiveness. The speedy problem is the dissection of key occasions regulating the steroid reaction of objective tissues to avoid development and enhance therapy of breast and prostate cancers.
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Extra resources for Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers
Cold Spring Harb Perspect Biol 2:a003178 36. Nilsen J, Brinton RD (2003) Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proc Natl Acad Sci U S A. 100:10506–10511 37. Castoria G, Migliaccio A, Di Domenico M, Lombardi M, de Falco A, Varricchio L, Bilancio A, Barone MV, Auricchio F (2004) Role of atypical PKC in estradiol-triggered G1/S progression of MCF-7 cells. Mol Cell Biol 24:7643–7653 38. Levin ER (2005) Integration of the extranuclear and nuclear actions of estrogen.
Espinosa JM, Emerson BM (2001) Transcriptional regulation by p53 through intrinsic DNA/ chromatin binding and site-directed cofactor recruitment. Mol Cell 8:57–69 3. Lidor Nili E, Field Y, Lubling Y, Widom J, Oren M, Segal E (2010) p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy. Genome Res 20:1361– 1368 4. Beato M, Herrlich P, Schütz G (1995) Steroid hormone receptors: many actors in search of a plot. Cell 83:851–857 5. Piña B, Brüggemeier U, Beato M (1990) Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter.
Progesterone treatment of cells in culture leads to the rapid activation of several kinases and in particular the Src/Ras/Erk/Msk1 cascade, by activating a small population of membrane-anchored progesterone receptors (PR). One to five minutes after hormone treatment, activated Erk enters the nucleus and causes the G. P. Vicent Á R. Zaurin Á C. Ballaré Á A. Silvina Nacht Á R. H. G. Wright Á F. Le Dily Á G. Castellano Á J. Font-Mateu Á M. eu G. P. eu R. eu C. eu A. eu R. H. G. eu F. eu G. eu J. eu G.
Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers by Gabriella Castoria, Antimo Migliaccio