Download e-book for iPad: Advances in Rapid Sex-Steroid Action: New Challenges and New by Gabriella Castoria, Antimo Migliaccio

By Gabriella Castoria, Antimo Migliaccio

ISBN-10: 1461417635

ISBN-13: 9781461417637

ISBN-10: 1461417643

ISBN-13: 9781461417644

Breast and prostate cancers are either hormone-dependent, a minimum of in a few phases in their development. Hormonal manipulation represents a major healing strategy. even though so much of breast and prostate cancers before everything reply to hormone remedy, such a lot tumors reinitiate to development. eventually, hormone-resistant and metastatic breast and prostate cancers may perhaps improve. hence, the problem is the dissection of mechanisms in which steroid receptor signaling pathways proceed to persuade telephone progress and invasiveness. Compelling facts shows that steroid hormones elicit non-genomic responses in extra-nuclear compartment of objective cells. during this mobile situation, steroid-coupled receptors quickly recruit signaling effectors or scaffold proteins and turn on a number of pathways resulting in proliferation, survival, migration and invasiveness. The speedy problem is the dissection of key occasions regulating the steroid reaction of objective tissues to avoid development and enhance therapy of breast and prostate cancers.

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Extra resources for Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers

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Progesterone treatment of cells in culture leads to the rapid activation of several kinases and in particular the Src/Ras/Erk/Msk1 cascade, by activating a small population of membrane-anchored progesterone receptors (PR). One to five minutes after hormone treatment, activated Erk enters the nucleus and causes the G. P. Vicent Á R. Zaurin Á C. Ballaré Á A. Silvina Nacht Á R. H. G. Wright Á F. Le Dily Á G. Castellano Á J. Font-Mateu Á M. eu G. P. eu R. eu C. eu A. eu R. H. G. eu F. eu G. eu J. eu G.

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Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers by Gabriella Castoria, Antimo Migliaccio

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