By Perkin G David
Any dialogue of the medical features of Parkinson's sickness needs to keep in mind the inaccuracies of scientific prognosis. In a successive sequence of a hundred sufferers with a scientific prognosis of Parkinson's sickness, merely seventy six fulfilled the factors for analysis at autopsy exam. makes an attempt to tighten the diagnostic standards bring about elevated specificity yet with diminished sensitivity.In An Atlas of Parkinson's disorder and comparable problems Dr. David Perkin has compiled a sequence of images highlighting numerous facets of Parkinson's sickness and comparable motor problems. The publication offers an invaluable pattern of medical, investigative (CT, MRI, and puppy) and pathological photographs with succinct descriptive textual content of the problems featured. nearly one-third of the cloth during this e-book is pathological, incorporating either macroscopic and microscopic sections. a different area of the fabric is represented through imaging, largely magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning. the realm of flow issues has been really fruitful for puppy scanning, which supplies, with the improvement of particular ligands for some of the receptor websites, to extra extend realizing of the pathophysiological mechanisms of the flow issues. Reflecting the top criteria medical images and imaging besides the celebrated author's specialist wisdom of the topic, Dr. Perkin's An Atlas of Parkinson's ailment and comparable issues is the definitive and crucial scientific reference in its box.
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Extra resources for An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series)
In particular, note the ulnar deviation at the wrist and the abducted posture of the little finger ©2004 CRC Press LLC A B C Figure 49 This patient with corticobasal degeneration shows ideomotor apraxia of the left hand. When asked to copy three hand postures (A–C, lower), in each instance, the patient's version was defective (A–C, upper) ©2004 CRC Press LLC Figure 50 In this patient with corticobasal degeneration, sagittal T1-weighted MRI (upper) shows predominantly posterior frontal and parietal atrophy (arrowed).
The main tremor peak is at approximately 5 Hz with a harmonic at 10 Hz ©2004 CRC Press LLC Figure 14 Positive glabellar tap. Persistent blinking is a feature of Parkinson’s disease, but is also seen in Alzheimer’s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject (upper) compared with a Parkinsonian patient (lower) ©2004 CRC Press LLC Nerve terminal + Levodopa 3,4-Dihydroxyphenylacetic acid Selegiline Levodopa dopa decarboxylase – monoamine oxidase-B Dopamine Amantadine + Glial cell Homovanillic acid reuptake Dopamine 3-Methoxytyramine COMT – Tolcapone + Bromocriptine Lysuride Pergolide Ropinirole Cabergoline Terminal expressing either D1 or D2 receptor Postsynaptic neuron Figure 16 Synthesis and metabolism of dopamine within the central nervous system.
The patient had presented with a Parkinsonian state with, eventually, predominant axial features Figure 26 Coronal brain section (same patient as in Figure 25) showing numerous small lacunes in the heads of both caudate nuclei and in the anterior part of the putamen ©2004 CRC Press LLC Figure 27 Histological sections from Parkinson's disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology showing a subthalamic neuron containing a globose neurofibrillary tangle in progressive supranuclear palsy (Bielschowsky silver impregnation) ©2004 CRC Press LLC A B C D Figure 29 In this patient with progressive supranuclear palsy, upward (A) and lateral gaze (B and C) are preserved whereas down gaze (D) is impaired ©2004 CRC Press LLC Figure 30 Attempted down gaze (left) shows improvement with the doll's-head maneuver (right) in this patient with progressive supranuclear palsy Figure 31 Sagittal T1-weighted MRI showing midbrain atrophy (arrowed) in progressive supranuclear palsy ©2004 CRC Press LLC Figure 32 11C-raclopride binding in a normal subject (left) compared with that in Parkinson's disease (middle) and in progressive supranuclear palsy (right).
An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series) by Perkin G David