Ankylosing Spondylitis and the Spondyloarthropathies: A by Michael H. Weisman MD, John D. Reveille, Desiree van der PDF

By Michael H. Weisman MD, John D. Reveille, Desiree van der Heijde

ISBN-10: 0323031048

ISBN-13: 9780323031042

Constructed as a spouse textual content to the third variation of the heralded Rheumatology, via Hochberg et al., this state of the art reference offers modern-day realizing of the spondylarthropathies. you will discover thorough examinations of the cutting edge, new remedies that problem older ideas of remedy and administration of the illness. famous specialists within the box additionally current the newest techniques in early analysis utilizing complicated imaging thoughts * state of the art wisdom of the pathogenetic and epidemiologic positive aspects * crucial new advancements in immunology * and the newest figuring out of the socio-demographic effect of the disease.Describes cutting edge therapy and administration suggestions that aid you supply sufferers with tremendous aid in soreness, morbidity, and the extra dire results of the disorder. allows quick connection with the disease's actual manifestations via entire assurance of its scientific elements. enables you to verify the efficacy of organic brokers according to the most recent insights on new treatments, together with anti-TNF. Assesses the advantages and boundaries of accessible imaging modalities within the analysis and administration of spondylarthropathies.

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Extra resources for Ankylosing Spondylitis and the Spondyloarthropathies: A Companion to Rheumatology 3E

Example text

Classical major histocompatibility complex class II genes The HLA-DR region is composed of one nonpolymorphic DRA gene whose product combines with the product of numerous DRB genes to form the HLA-DR heterodimers. 1). The presence and number of other DRB loci vary on different HLA-DR haplotypes. The HLA-DQ molecule is composed of the product of the two DQA and two DQB genes, with only one of each (DQA1 and DQB1) encoding a functional product. HLA-DP is the last and most centromeric-lying of the classical class II loci to be described.

Steiner NK, Gans C, Baldassarre L, et al. Twenty-five novel HLA-B alleles. Tissue Antigens. 2003;62:263–266. 29. Ramos M, Lopez de Castro JA. HLA-B27 and the pathogenesis of spondyloarthritis. Tissue Antigens. 2002;60:191–205. 30. Boyle LH, Gaston JS. Breaking the rules: the unconventional recognition of HLA-B27 by CD4+ T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies. Rheumatology (Oxford) 2003;42:404–412. 31. Boyle LH, Goodall JC, Opat SS, Gaston JS. The recognition of HLA-B27 by human CD4+ T lymphocytes.

20. Wei J, Hemmings GP. TNXB locus may be a candidate gene predisposing to schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004;125:43–49. 21. Lindor NM, Bristow J. Tenascin-X deficiency in autosomal recessive Ehlers-Danlos syndrome. Am J Med Genet A. 2005;135:75–80. 22. Tazi-Ahnini R, Cork MJ, Wengraf D, et al. NOTCH4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. Hum Genet. 2003;112:400–403. 23. Schmidt AM, Stern DM. Receptor for AGE (RAGE) is a gene within the major histocompatibility class III region: implications for host response mechanisms in homeostasis and chronic disease.

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Ankylosing Spondylitis and the Spondyloarthropathies: A Companion to Rheumatology 3E by Michael H. Weisman MD, John D. Reveille, Desiree van der Heijde

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