By Richard O. Day, Daniel E. Furst, Piet L.C.M. van Riel, Barry Bresnihan
This ebook provides a complete review of disease-modifying antirheumatic medicines (DMARDs). The introductory common chapters take care of the chemistry of DMARDs, their use in remedy, pharmacoeconomics, and a survey of opinion leaders within the box; the subsequent particular chapters signify each one agent with reference to mechanism of motion, treatment, pharmacology, efficacy, toxicity, and tracking. for every agent a few history is given, fresh advancements and impact of the remedy on sufferers` caliber of lifestyles and long term results are awarded.
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Extra info for Antirheumatic Therapy: Actions and Outcomes (Progress in Inflammation Research)
In general, using indirect comparisons, no major differences are 30 Targeting DMARD therapy observed between traditional DMARDs when adjusting for placebo effects with measures such as NNT. Only biologic agents appear to offer some advantages over other drugs in short-term studies . These benefits seem more pronounced in patients with longer disease duration who have failed other therapies. For DMARD-naoive patients, although some significant differences have been observed in the rate of radiological progression when comparing traditional DMARDs with biologic agents, other clinical difference s are small [29,30].
The most studied genes in RA are those in the HLA region, yet the role of the shared epitope in therapeutic response remains somewhat debatable. In the MIRA trial comparing minocycline to placebo, an interaction between the presence of the shared epitope and treatment group was observed . In the group treated with minocycline, no differences were observed in radiological progression between DR4 positive and negative patients. However, in the placebo group, a gradient was observed, with increased radiological damage according to the allele dose (none, heterozygous, and homozygous) .
Science 244: 41-47 Weinshilboum R (2001) Th iopurine pha rmacogn etics: clinical and molecular studies of thiopurine methylpur ine tran sferase. Drug Metab Disp 29: 601-605 Marra CA, Esdaile JM, Anis AH (2002) Practical pharm acogenetics: the cost effectiveness of screening for thiopurine S-transmethylase (TPMT) polymorphisms in pat ients with rheumatological conditi ons treated with azathioprine. ] Rheumat ol29: 250 7-2512 Seidman EG, Furst DE (2002) Pharmacogenetics for the individualizat ion of treatment of rheumatological disorders using azathioprine.
Antirheumatic Therapy: Actions and Outcomes (Progress in Inflammation Research) by Richard O. Day, Daniel E. Furst, Piet L.C.M. van Riel, Barry Bresnihan