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Extra resources for Aplicaciones Ortodвnticas en Implantes

Example text

50 References . . . . . . . . . . . . . . . . . . . . . . . . . 51 Abstract Multiple sclerosis1 (MS) is an immune-mediated autoimmune demyelinating disease in humans. The initiating event in MS is unknown, but epidemiological evidence suggests that virus infections may be important and one possible mechanism for induction of infection-induced autoimmune disease is molecular mimicry. To test the ability of a virus encoding a self myelin mimic epitope to induce an autoimmune response, we have developed a mouse model wherein the immunodominant myelin epitope PLP139–151 , or mimics of this epitope, were inserted into a nonpathogenic variant of Theiler’s murine encephalomyelitis virus (TMEV).

Neuroimmunol. D. 2001. A virusinduced molecular mimicry model of multiple sclerosis. J. Clin. Invest. D. 2002. Functional activation of myelin-specific T cells by virus-induced molecular mimicry. J. Immunol. , Cantor H. 2001. Analysis of the relationship between viral infection and autoimmune disease. M. 1994. Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93–103). J. Immunol. A. 1995. Campylobacter jejuni infection and Guillain-Barre syndrome.

40 2 Virus-Induced Molecular Mimicry Model of Multiple Sclerosis . . . . 42 3 Haemophilus influenzae Is a Molecular Mimic of PLP139–151 . . . . . 45 4 Multiple Infections with Molecular Mimic-Encoding Pathogens Increase Disease Severity . . . . . . . . . . . . . . . . . 47 5 Infection of the Target Organ Is Not Required for Autoimmune Disease Induced by Molecular Mimicry . . . . . . . . . . . . . . . 47 6 Model for Molecular Mimicry Induced Autoimmune Demyelinating Disease .

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Aplicaciones Ortodвnticas en Implantes


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