Download PDF by Nigel Arden, Francisco Blanco, C. Cooper, Ali Guermazi,: Atlas of Osteoarthritis

By Nigel Arden, Francisco Blanco, C. Cooper, Ali Guermazi, Daichi Hayashi, David Hunter, M. Kassim Javaid, Francois Rannou, Frank Roemer, Jean-Yves Reginster

ISBN-10: 191031515X

ISBN-13: 9781910315156

ISBN-10: 1910315168

ISBN-13: 9781910315163

This Atlas offers an up to date and entire assessment of the historic and present views on osteoarthritis, together with the pathophysiology and epidemiology of the sickness. Written via top authors within the box of osteoarthritis, the booklet discusses type, etiology and possibility components for osteoarthritis, the sickness path and determinants of osteoarthritis development, medical positive aspects and analysis in addition to imaging how you can determine joint harm. The Atlas of Osteoarthritis concludes with the newest therapy updates together with either nonpharmacological and pharmacological remedies, in addition to surgical techniques for sufferers with the disorder. Osteoarthritis is the most typical kind of joint illness inflicting joint soreness, stiffness, and actual incapacity between adults. it truly is an enormous factor for either the person and society with its influence on public overall healthiness carrying on with to develop due to the getting older inhabitants, the emerging occurrence of weight problems, and the shortcoming of definitive remedies to avoid or halt the development of the disease.

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Extra resources for Atlas of Osteoarthritis

Sample text

ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; BMP, bone morphogenetic protein; CCL2, CC-chemokine ligand 2; CXCL13, CXC-chemokine ligand 13; EGF, endothelial growth factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; IL-1Ra, IL-1 receptor antagonist; LIF, leukaemia inhibitory factor; LTB4, leukotriene B4; MMP, matrix metalloproteinase; NAMPT, nicotinamide phosphoribosyl transferase (also called visfatin); NGF, nerve growth factor; PGE2, prostaglandin E2; TIMP, tissue inhibitor of metalloproteinase; TNF, tumour necrosis factor; VCAM-1, vascular cell adhesion molecule 1; VEGF, vascular endothelial growth factor.

Cartilage degradation Under normal conditions, the physiologic homeostasis of the articular cartilage is driven by chondrocytes, which produce the structural matrix containing collagens (primarily collagen 39 Atlas of osteoarthritis Discovertebral osteoarthritis of the spine type II), and proteoglycans [6,13]. 5 Discovertebral osteoarthritis of the spine. Anteroposterior radiograph of the lower lumbar spine shows endplate-based sclerosis in the L4 lower and L5 upper end-plates with narrowing of the disc space between them (arrow).

Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham study. Arthritis Rheum. 1997;40:728-733. 43 Spector T, Hart D, Doyle D. Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. Ann Rheum Dis. 1994;53:565-568. 44 Gelber A, Hochberg M, Mead L, Wang N, Wigley F, Klag M. Body mass index in young men and the risk of subsequent knee and hip osteoarthritis. Am J Med. 1999;107:542-548. 45 Cooper C, Snow S, McAlindon T, et al.

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Atlas of Osteoarthritis by Nigel Arden, Francisco Blanco, C. Cooper, Ali Guermazi, Daichi Hayashi, David Hunter, M. Kassim Javaid, Francois Rannou, Frank Roemer, Jean-Yves Reginster


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