George Tsokos's Systemic lupus erythematosus : basic, applied and clinical PDF

By George Tsokos

ISBN-10: 0128019174

ISBN-13: 9780128019177

Systemic Lupus Erythematosus combines simple technological know-how with scientific technological know-how to supply a translational therapy of the disorder and is an invaluable reference for experts within the prognosis and administration of sufferers with SLE, a device for size of scientific job for pharmaceutical improvement and uncomplicated study of the sickness and a reference paintings for clinic libraries.

  • Provides the very most recent review of the pathogenesis of SLE
  • Distills present realizing of the mobile, molecular, genetic and environmental elements that instigate and force the disease
  • Includes complete insurance of medical positive factors, together with fatigue, organ approach manifestations, overlap syndromes, infections, and more
  • Conveys the very newest figuring out of mechanisms of tissue harm, together with immune complexes, antibodies, and different mechanisms that result in organ damage
  • Discusses the most recent therapies on affliction editing or disorder controlling agents
  • Provides 'one cease' assurance of the entire newest clinical and scientific advancements in SLE

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Additional resources for Systemic lupus erythematosus : basic, applied and clinical aspects

Example text

Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002;29:288–91. Merrill JT, Buyon JP. Connective tissue diseases: what does the death of Riquent hold for the future of SLE? Nat Rev Rheumatol 2009;5(6):306–7. Merrill JT, Erkan D, Buyon JP. Challenges in bringing the bench to bedside in drug development for SLE. Nat Rev Drug Discov 2004;3(12):1036–46. Thanou A, Chakravarty E, James JA, Merrill JT. Which outcome measures in SLE clinical trials best reflect medical judgment?

60 CONCLUSIONS Outcomes in SLE patients have changed over the years. Decreased survival was initially from disease activity. Medical treatment advances have led to improved survival, but SLE patients still have a three times higher risk of death than the general population. The trend toward improved survival is also counterbalanced by accrual of organ damage. Physicians must adequately address disease activity and minimize disease damage. Inclusion of patient-reported outcomes in the assessment of disease control has also become a priority.

8 Case series of ANA-negative patients suggest a higher frequency of photosensitive rash and milder renal and central nervous system (CNS) disease than ANA-positive patients. Disease manifestations and course in patients with undetectable ANA may otherwise be typical of classical SLE. 8 Systemic Lupus Erythematosus. 00005-X Copyright © 2016 Elsevier Inc. All rights reserved. 9 Another group of patients with “latent” or “incomplete” lupus has been identified. 10 For example, incomplete lupus patients will exhibit one or two of the ACR classification criteria plus other nonspecific clinical characteristics, such as fever, fatigue, headache, lymphadenopathy, or neuropathy.

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Systemic lupus erythematosus : basic, applied and clinical aspects by George Tsokos


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